Three-Dimensional Hydrodynamic Focusing Method for Polyplex Synthesis
نویسندگان
چکیده
منابع مشابه
Three-dimensional hydrodynamic focusing method for polyplex synthesis.
Successful intracellular delivery of nucleic acid therapeutics relies on multiaspect optimization, one of which is formulation. While there has been ample innovation on chemical design of polymeric gene carriers, the same cannot be said for physical processing of polymer-DNA nanocomplexes (polyplexes). Conventional synthesis of polyplexes by bulk mixing depends on the operators' experience. The...
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Shape-controlled synthesis of nanomaterials through a simple, continuous, and low-cost method is essential to nanomaterials research toward practical applications. Hydrodynamic focusing, with its advantages of simplicity, low-cost, and precise control over reaction conditions, has been used for nanomaterial synthesis. While most studies have focused on improving the uniformity and size control,...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2014
ISSN: 1936-0851,1936-086X
DOI: 10.1021/nn404193e